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Chromokinesin

WebJul 24, 2024 · Here, we present a novel abscission mechanism. We identified chromokinesin KIF4A, which is adjacent to the midbody during cytokinesis, as being required for efficient abscission. KIF4A is regulated by post-translational modifications. We evaluated modification of KIF4A by the ubiquitin-like protein SUMO. We mapped lysine … WebThe chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells. Assessment of KIF22 function requires quantitative comparison of relative polar ejection forces between experimental conditions. This is facilitated by the generation of ...

Chromokinesins - PubMed

WebMar 16, 2024 · The chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain … WebHere, we describe a live-cell PEF assay in which tension was applied to chromosomes by manipulating levels of the chromokinesin NOD (no distributive disjunction; Drosophila m... More Keywords. Article Link > Most Popular Services. Homology-Directed Repair (HDR) Knock-in Templates. CRISPR Cas9 Single guide RNA (sgRNA) and Ribonucleoprotein … how find the median https://chriscrawfordrocks.com

Chromokinesin KIF4A teams up with stathmin 1 to regulate …

WebMay 1, 2016 · Chromokinesin contains both a kinesin motor-like domain and an unusual basic-leucine zipper DNA-binding domain. Its mRNA is readily detectable in proliferating cells, but not in postmitotic cells. WebJun 27, 2024 · The chromokinesin KIF4A associates with microtubules and contributes to chromosome segregation during mitosis. Here, we show that this function depends on a … WebJan 1, 2024 · Abstract The chromokinesin KIF22 (Kid, kinesin-10 family) is the primary generator of polar ejection forces, which contribute to chromosome positioning and alignment in mitotic cells. Assessment of KIF22 function requires quantitative comparison of relative polar ejection forces between experimental conditions. how find the circumference of a circle

Chromokinesin: Kinesin superfamily regulating cell division through ...

Category:Human chromokinesin KIF4A functions in chromosome …

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Chromokinesin

The human chromokinesin Kid is a plus end‐directed …

WebJul 24, 2024 · (A) Chromokinesin KIF4A is required for the positioning of mitotic chromosomes and stabilization of the bipolar spindle. In cytokinesis, KIF4A localizes at … WebSep 30, 2024 · The chromokinesin KIF22 uses plus end-directed motility and direct binding to chromosome arms to generate pushing forces that contribute to mitotic chromosome …

Chromokinesin

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WebSep 30, 2024 · The chromokinesin KIF22 uses plus end-directed motility and direct binding to chromosome arms to generate pushing forces that contribute to mitotic chromosome congression and alignment. Mutations in the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient … WebJul 1, 2008 · Chromokinesins are microtubule-motor molecules that possess chromatin binding activity and are important for mitotic and meiotic regulation. The chromokinesin-member Kif4A is unique in that it localizes to nucleus during interphase of the cell cycle. Kif4 deletion by gene targeting in mouse embryoni …

Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 WebJul 1, 2005 · Figure 1 Molecular structure and cellular localization of chromokinesins. (a) Schematic domain structure of Kinesin-4 and Kinesin-10.(b) Localization of chromokinesin HKIF4A and effects on mitosis upon its loss. (top row) Human KIF4A localizes to the nucleus during interphase, associates with mitotic chromosomes during early mitosis and …

WebJul 1, 2005 · Download : Download full-size image Figure 1. Molecular structure and cellular localization of chromokinesins. (a) Schematic domain structure of Kinesin-4 and Kinesin-10.(b) Localization of chromokinesin HKIF4A and effects on mitosis upon its loss. (top row) Human KIF4A localizes to the nucleus during interphase, associates with mitotic …

WebAug 23, 2004 · Chromokinesins represent a family of chromosome arm-binding kinesins consisting of two distinct types of members: chromokinesins/KIF4 and the Kid …

WebThe chromokinesin KIF22 generates forces that contribute to mitotic chromosome congression and alignment. Mutations in the α2 helix of the motor domain of KIF22 have been identified in patients with abnormal skeletal development, and we report the identification of a patient with a novel mutation in the KIF22 tail. higher power outfitters inc. punta gorda flWebSep 30, 2013 · Here we show that a quantum dot (Qdot) binding up to four Xenopus chromokinesin (Xkid) molecules behaved like a nanosize chromosome arm in the meiotic spindle, which is self-organized in ... higher power in the universeWebMar 6, 2015 · The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J. Cell Biol. 154 , 1135–1146 (2001) . higher power outfitters punta gorda flWebSep 30, 2013 · Here we show that a quantum dot (Qdot) binding up to four Xenopus chromokinesin (Xkid) molecules behaved like a nanosize chromosome arm in the … higherpowerradioWebSep 1, 2016 · As a vital kind of kinesin, chromokinesin functions in different kinds of cells and organisms, from nerve cells to germ cells, from Drosophila to human. We have … higher power north dakotaWebOct 8, 2024 · Chromokinesins are members of the kinesin superfamily that harbour a specific DNA-binding domain. The best characterized chromokinesins belong to the … higher power towing jaxWebBackground: Despite the significant survival benefits of anti-PD-1/PD-L1 immunotherapy, non-small cell lung cancer (NSCLC) remains one of the most common tumors and major causes of cancer-related deaths worldwide. Thus, there is an urgent need to identify new therapeutic targets for this refractory disease. Methods: In this study, microarray datasets … higher power hangar door