WebDec 31, 2024 · Special Issue Information. Dear Colleagues, Autophagy (“auto-digestion”), a lysosome-dependent process, degrades and turnovers damaged or senescent organelles and proteins. Autophagy is a highly-regulated process, which impacts several vital cellular responses, including inflammation, cell death, energy metabolism and organelles ... WebApr 25, 2014 · The role of autophagy in cisplatin-induced AKI is discussed in the next section. 4.2. Autophagy Autophagy is a cellular process of “self-eating” in which …
HDAC6 Inhibition Alleviates Ischemia- and Cisplatin-Induced …
WebThe apoptosis induced by cisplatin in mice increased evidently compared with the control group, which was decreased in the mice with neferine pretreatment. What' more, we found that autophagy increased obviously in mice pretreated by neferine contrast to … WebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who are receiving cisplatin ... how does cinnamon taste
Myo-Inositol Supplementation Alleviates Cisplatin-Induced Acute …
WebAcute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide … Web1 day ago · In this study, a natural product from Osage Orange, pomiferin, was identified as a novel autophagy activator that circumvents innate resistance by triggering autophagic cell death via SERCA inhibition and activation of the CaMKKβ-AMPK-mTOR signaling cascade. In addition, pomiferin also directly inhibited the P-gp (MDR1/ABCB1) efflux and ... WebThe delivery of an approved agent such as rapamycin in a PFC NP format enhances local delivery and offers a novel mechanism-based prophylactic therapy for cisplatin-induced acute kidney injury. For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10–20% of all cancer patients. … how does cinnamon tea help you