Cisplatin hela
WebFeb 1, 2015 · In cell proliferation experiments, HeLa cells were treated with either cisplatin or myricetin and methyl eugenol alone, or vehiclealone for 12, 24 and 48 h. For apoptosis assay, cells weretreated with cisplatin or myricetin and methyl eugenol either alone or combined, or vehicle alone for 48 h. WebOct 1, 2024 · The present study using network pharmacology revealed that salicylic acid and cisplatin shared common genes related to apoptosis in cervical cancer. Salicylic acid …
Cisplatin hela
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WebJan 20, 2024 · Further investigation revealed that cisplatin-resistant cells sustain OXPHOS partly via iron metabolism reprogramming during glutamine deprivation. This reprogramming might be responsible for mitochondrial iron-sulfur [Fe-S] cluster biogenesis, which has become an "Achilles' heel," rendering cancer cells vulnerable to DFO-induced autophagic ... WebJul 22, 2024 · In contrast, artesunate preferably accumulates in lysosomes, activates lysosome function, and promotes ferritin degradation and free ferrous (Fe 2+) release in HeLa cervical cancer cells . This artesunate-mediated effect on the lysosome and cellular iron accumulation may also occur in HCC cells, and artesunate may further synergize …
WebFeb 10, 2024 · Cisplatin is one of the most effective chemotherapy drugs and is widely used in the treatment of cancer, including hepatocellular carcinoma (HCC) and … WebMay 1, 1996 · The intraperitoneal (i.p.) administration of cisplatin (CDDP) is one of the most effective therapies for cancers that are confined to the abdominal cavity. However, the …
WebJul 2, 2024 · To ascertain this, we determined effect of PARP-1 inhibition on cisplatin cytotoxicity in HeLa and SiHa cell lines. Combination of cisplatin with PJ34, a phenanthridinone-derived PARP-1 inhibitor, augmented cisplatin toxicity in vitro by decreasing cell proliferation, enhancing cell cycle block and cell death, and decreasing … WebResults: HeLa and SiHa cells were more sensitive to cisplatin and oxaliplatin treatment than C33A cells. HeLa and SiHa cells had significantly lower NRF2 gene levels, NQO1 …
WebSep 10, 2010 · Cisplatin has been widely accepted as one of the most efficient anticancer drugs for decades. However, the mechanisms for the cytotoxic effects of cisplatin are still not fully understood. Cisplatin primarily targets DNA, resulting in the formation of DNA double strand breaks and eventually causing cell death.
WebCisplatin is a platinum chemotherapeutic used in a variety of malignancies. The antineoplastic activity occurs from DNA cross-links and adducts, in addition to the generation of superoxide radicals. Nephrotoxicity is the most well-known and potentially most clinically significant toxicity. north coast 500 trafficWebCisplatin, as a significant chemotherapeutic drug for the treatment of cancers, was combined with rapamycin (RAPA), an autophagy inducer, or 3-methyladenine (3-MA), an autophagy inhibitor, and these cisplatin … how to reset pattern lock in samsungWebIn order to assist in optimizing treatment, we applied 5-ALA/PDT in combination with low-dose cisplatin to evaluate cytotoxicity in Hela cells. Methods: Antiproliferative effects of 5-ALA/PDT and cisplatin, alone and in combination, were assessed using MTT assay. north coast aboriginal corporationhow to reset pc for autopilotWebAbstract. To study the apoptosis induced by cisplatin in cervical cancer cell line HeLa and its mechanism, cell growth inhibition of cisplatin on HeLa cells was analyzed by … north coast aims conferenceWeb1 day ago · To further confirm the autophagic effect, the expression level of LC3 was detected by immunoblot analysis in HeLa cells, an appropriate tool cells for ... Pomiferin potentiates the tumor suppression effect of cisplatin via attenuating ABCB1 activity and promoting cisplatin accumulation in tumor tissues of RM-1 drug-resistant prostate ... north coast administratorsWebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes … north coast aboriginal health