Citrate transporter family protein

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August undefined, 2024

WebThe citrate carrier (CiC), a nuclear-encoded protein located in the mitochondrial inner membrane, is a member of the mitochondrial carrier family. CiC plays an important role … WebJul 1, 2007 · The cellular transport of long-chain fatty acids (LCFAs) across the plasma membrane has long been thought to occur via passive diffusion. However, in recent years a substantial body of literature has emerged indicating that LCFA uptake into muscle cells occurs via a protein-mediated process (for review see Bonen et al. 2002; Luiken et al. …

Structure and inhibition mechanism of the human citrate transporter

WebMar 1, 2024 · The Mitochondrial Carrier Family. With 53 members, the mitochondrial carrier family (solute carrier family 25, SLC25) is the largest solute transporter family in humans. They transport solutes across the impermeable inner membrane of mitochondria for important cellular processes, such as oxidative phosphorylation of fats and sugars, … WebFeb 17, 2024 · Liver cells import citrate through the sodium-dependent citrate transporter NaCT (encoded by SLC13A5) and, as a consequence, this protein is a potential target for anti-obesity drugs. dauphin county library careers

Molecular Mechanism of Citrate Efflux by the Mitochondrial Citrate ...

WebAluminum-activated malate transporter 1. Gene. ALMT1. Status. UniProtKB reviewed (Swiss-Prot) ... Al tolerance QTL also found on chromosome 1. Acts in parallel but independently of MATE, an aluminum-activated root citrate transporter. ... Protein family/group databases. TCDB. 2.A.85.2.3 the aromatic acid exporter (arae) family; … WebFeb 12, 2024 · As the prototype for the TTT family, the TctC citrate transporter was first described by Sweet et al. (1979) in the pathogen Salmonella typhimurium, one of the most important causative agents of food-borne gastrointestinal infections and a growing problem due to the recent emergence of multidrug resistant strains (Hur et al., 2012). WebCitrate plays a pivotal role not only in the generation of metabolic energy but also in the synthesis of fatty acids, isoprenoids, and cholesterol in mammalian cells. Plasma levels … dauphin medical clinic physicians

Inhibition of the mitochondrial citrate carrier, …

SLC13A2 solute carrier family 13 member 2 [ (human)]

WebNov 14, 2008 · Recently, three studies have reported that some MATE proteins are involved in the transport of citrate, which is required for iron (Fe) translocation or … WebCitrate transporter family protein Imported. Gene names. Ordered locus names. PFL_2499 Imported. Organism names. Organism. Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) Imported. Taxonomic … dauphin county jailWebSep 29, 2012 · The 2-oxoglutarate carrier (OGC) belongs to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors and nucleotides between the cytoplasm and mitochondrial matrix. Initially, OGC was characterized by determining substrate specificity, kinetic parameters of transport, … dauphin county pa assessment parcel search

"WebSLC25 is the largest solute transporter family in humans. 53 members have been ... (SLC25A1, or citrate transport protein; TC# 2.A.29.7.2) Graves disease carrier protein … " - Citrate transporter family protein

Citrate transporter family protein

Structure and inhibition mechanism of the human citrate …

WebDec 15, 2024 · Iacobazzi et al. (1997) determined that the open reading frame of the human citrate transporter gene encodes a mature protein of 298 amino acids and a … WebNational Center for Biotechnology Information

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WebFeb 11, 2002 · Citrate transport protein (CTP) Mitochondrial citrate carrier 1 publication (CIC 1 publication) Solute carrier family 25 member 1; Tricarboxylate carrier protein; … WebThis gene encodes a sodium-driven citrate transport protein named NaCT. Disease-causing mutations abolish the uptake of citrate in neurons of the brain. ... (NaDC) from the SLC13 family. A number of mutations have been identified in the NaCT transporter gene (SLC13A5) in patients with epileptic encephalography. The Pajor Lab explores what …

WebThe partially compromised nodule functioning induces two striking phenotypes: anthocyanin accumulation already displayed 4 weeks after inoculation and shoot biomass deficiency, which is detected by long-term phenotyping. LjNPF8.6 achieves nitrate uptake in Xenopus laevis oocytes at both 0.5 and 30 mm external concentrations, and a possible role ... WebMar 21, 2024 · This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may …

WebOct 10, 2013 · The SLC13 family in humans and other mammals consists of sodium-coupled transporters for anionic substrates: three transporters for dicarboxylates/citrate and two transporters for sulfate. This review will focus on the di- and tricarboxylate transporters: NaDC1 (SLC13A2), NaDC3 (SLC13A3), and NaCT (SLC13A5). The substrates of these … WebThis gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate …

WebDec 9, 2024 · The citrate transporter protein (CTP) plays an important role in citrate efflux from the mitochondrial matrix to cytosol that has great importance in oleaginous fungi. ... Most mitochondrial carrier family proteins (MCF) are small, with a length of around 300 amino acids and a molecular weight ranging from 30 to 35 kDa . The hydrophobic ...

WebSLC13A5. Solute carrier family 13 (sodium-dependent citrate transporter), member 5 also known as the Na+/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene. [5] It is the mammalian homolog of the fly Indy gene . davcoadvertising.com/fileshareWebMay 14, 2024 · The citrate transport activity of the protein was studied in CT reconstituted liposomes. Our results showed high efficiency of CT for [ 14 C] citrate/citrate exchange with K m 0.01 mM at 25°C. dauphin county pennsylvania zip codesWebTricarboxylate transport protein, mitochondrial, also known as tricarboxylate carrier protein and citrate transport protein (CTP), is a protein that in humans is encoded by … davante adams highlights youtubeWebet al., 2004). Functional gene variants of transport proteins are involved in human diseases, and about 10% of established T2D loci are related to membrane transporters. II. Solute Carrier Membrane Transport Proteins Solute carrier (SLC) proteins are a group of trans-membrane transporters that mediate solute influx davanti winter tyres reviewsWebApr 4, 2024 · The encoded protein may play a role in the formation of kidney stones. [provided by RefSeq, Oct 2016] Other designations. solute carrier family 13 member 2, Na(+)-coupled citrate transporter, Na(+)/dicarboxylate cotransporter 1, renal sodium/dicarboxylate cotransporter, solute carrier family 13 (sodium-dependent … dauphin island al gulf breeze motelWebMar 11, 2016 · Multidrug and toxic compound extrusion (MATE) family is the most recent categorized multidrug efflux transporter family, which is a secondary transporter family that couples the translocation of substrates with an electrochemical gradient of cations (such as H + or Na + ions) across the membrane [1, 2].The X-ray structure of the MATE … davao city flowersWebOct 29, 2024 · Summary. This gene encodes a member of the mitochondrial carrier family. The encoded protein is responsible for the movement of tricarboxylates, such as citrate, across the inner mitochondrial membrane. It is essential to the bioenergetics of hepatic cells, supplying the cytoplasm with a carbon source for fatty acid and sterol biosynthesis, and ... dave and ang photography