Nis in thyroid

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August undefined, 2024

WebJan 28, 2024 · Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), and their regulators such as thyrotropin receptor (TSHR), thyroid transcription factor-1 (TTF-1), thyroid transcription … WebThe rat thyroid model was then extrapolated to humans using human . in vitro . HTS data for NIS inhibition and the chemical specific hepatic clearance rate in humans. The overall …

TSH effects on NIS expression and function in thyroid cells. A, I ...

WebThis assay investigates the transport of iodine via the NIS into the thyroid follicular cells. Chemicals can inhibit iodine uptake by competing with iodine for binding to the NIS … WebJan 18, 2016 · Being a member of the solute carrier transporter (SLC5A5), NIS is an intrinsic plasma membrane glycoprotein that mediates active iodide transport in thyroid follicular cells. NIS mediated iodide ... moulting in cockatiels

High Throughput in vitro chemical screening for thyroid target …

WebMay 27, 1997 · NIS (Na + /I − symporter) is a key plasma membrane protein that catalyzes the active accumulation of iodide (I −) in the thyroid gland, a major step in the biosynthesis of thyroid hormones thyroxine (T 4) and tri-iodothyronine (T 3 ). WebExpression of the sodium iodide symporter (NIS) is required for efficient iodide uptake in thyroid and lactating breast. Since most differentiated thyroid cancer expresses NIS, β … WebMay 27, 1997 · The cDNA encoding NIS was recently cloned by functional screening of a cDNA library from a rat thyroid-derived cell line (FRTL-5 cells) in Xenopus laevis oocytes … moulting hormone

In vitro to In vivo (IVIVE) and Species Extrapolation for the ...

Nis in thyroid

The Sodium Iodide Symporter (NIS): Regulation and …

WebNIS has the benefit of having both reporter gene and therapeutic functions, therefore, NIS gene transfer makes it possible to visualize, monitor, and treat tumors with suitable … WebThe rat thyroid model was then extrapolated to humans using human . in vitro . HTS data for NIS inhibition and the chemical specific hepatic clearance rate in humans. The overall species extrapolated PBPK-thyroid kinetics model can be used to predict dose-response (% drop in thyroid serum levels compared to homeostasis) relationships in humans.

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WebNov 1, 2002 · The NIS is a membrane-bound glycoprotein cotransporter expressed by thyroid, salivary, gastric, mammary, and extraocular tissues (1–4).NIS is essential for the uptake of iodide and thyroid ... WebNational Center for Biotechnology Information

WebThe sodium-iodide symporter (NIS) is a member of the sodium/solute symporter family that actively transports iodide across the membrane of the thyroid follicular cells. In 1996, NIS mRNAs from rats 52 and humans 53 were isolated. The human gene (SLC5A5) maps to chromosome 19p13.2-p12. WebMay 30, 2014 · As illustrated in Figure 1, the NIS ( SLC5A5), a member of the solute carrier family 5, located at the basolateral plasma membrane of the thyroid follicular cells actively transports iodide into the thyroid using the electrochemical gradient generated by the Na,K-ATPase [ 9 – 11 ].

WebJun 9, 2010 · It is well known that NIS expression in thyroid is regulated by the thyroid statuses mainly through thyroid stimulating hormone (TSH). Although NIS mRNA expressions in extrathyroidal tissues have been qualitatively reported, their regulation by thyroid statuses has not been well clarified. Methods WebMar 31, 2024 · The sodium/iodide symporter (SLC5A5, also named as NIS) is a key cytomembrane glycoprotein that mediates active transport of iodide in the thyroid, which plays a central role in the treatment of DeTC ( 9 – 11 ).

WebResults: NIS is highly expressed in the basolateral membranes of the majority of striated ducts, yet weakly expressed in few intercalated and excretory duct cells. The ratio of (123)I accumulation between parotid and submandibular glands is 2.38±0.19.

WebJun 9, 2010 · It is well known that NIS expression in thyroid is regulated by the thyroid statuses mainly through thyroid stimulating hormone (TSH). Although NIS mRNA … healthy twitterWebApr 5, 2024 · Na+/I-symporter (NIS) is a key player in the RAI-based treatment of DTC [ 15 ]. NIS transports two Na + into the cell in an anterograde direction, and co-transports one I - into the cell in the reverse direction, establishing a stable 20- to 40-fold I - concentration gradient in thyroid follicular cells [ 16 ]. moulting lagoon eco toursWebAn iodide transport defect, a result of impaired iodide transport by the NIS protein mechanism, is rare and is reflected in defective iodide transport in the thyroid, salivary gland, and gastric mucosa. 144,145 Some mutations in such patients produce reduced activity, and others completely inactivate NIS by preventing the protein from being ... moulting insect