Phosphate carrier protein mitochondrial
WebSep 23, 2008 · The closed vesicular structure of mitochondria is functionally essential for the chemiosmotic mechanism of oxidative phosphorylation ( 1 ), that is, a direct link … WebMay 1, 2008 · Mitochondrial VDAC1 and Phosphate Carrier Protein Received for publication, November 9, 2007, and in revised form, January 14, 2008 Published, JBC Papers in Press, February 4, 2008, DOI 10.1074 ...
Phosphate carrier protein mitochondrial
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WebMitochondrial Carrier. Mitochondrial carriers (MCs) are a large family of membrane-embedded proteins that are mostly localized in the inner membrane of mitochondria. … WebFeb 5, 2008 · Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane.
WebThe protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. WebMentioning: 4 - The effect of protein labeling agents on coenzyme A (CoA) transport into isolated rat heart mitochondria was studied. CoA transport was substantially inhibited by sulfhydryl reagents (mersalyl, pCMB) as well as by the tyrosine-selective reagent N-acetylimidazole. The effect of pCMB was reversed by DTT. Moreover, CoA uptake was …
WebSep 1, 2024 · Here, we investigated cardiac pathways activated in response to mitochondrial energy dysfunction by studying mice with cardiomyocyte-specific loss of the mitochondrial phosphate carrier (SLC25A3), an established model that develops cardiomyopathy as a result of defective mitochondrial ATP synthesis. Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene. The encoded protein is a transmembrane protein located in the mitochondrial inner membrane and catalyzes the transport of phosphate ions across it for the purpose of oxidative phosphorylation. There are two … See more The SLC25A3 gene is located on the q arm of chromosome 12 in position 23.1 and spans 8,376 base pairs. The gene has 9 exons and produces a 40.1 kDa protein composed of 362 amino acids. The encoded protein … See more The encoded protein (PHC) catalyzes the transport of phosphate from the cytosol into the mitochondrial matrix, either by proton See more The encoded protein interacts with PPIF; this interaction is impaired by CsA. See more • Dolce V, Fiermonte G, Messina A, Palmieri F (1992). "Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier". DNA Sequence. 2 (2): … See more Mutations in this gene can cause mitochondrial phosphate carrier deficiency (MPCD), a fatal disorder of oxidative phosphorylation. Symptoms include lactic acidosis, … See more • Solute carrier family See more
WebGene ID: 128045351, updated on 28-Feb-2024. Summary Other designations. phosphate carrier protein, mitochondrial-like
WebOverview: oxidative phosphorylation The electron transport chain is a series of proteins and organic molecules found in the inner membrane of the mitochondria. Electrons are passed from one member of the transport chain to another in a series of redox reactions. eagle id fly fishingWebA transport protein is located in the inner mitochondrial membrane that exports ATP and imports ADP, the adenine nucleotide carrier. The inorganic phosphate necessary for the … csit vs itWebThis proton gradient is then used by the ATP synthase complex to produce ATP from ADP and inorganic phosphate. CoQ6 is an integral component of the ETC, as it is involved in the biosynthesis of ubiquinone, a key electron carrier in the chain. The ETC comprises four protein complexes (I-IV) that are arranged in the mitochondrial inner membrane. eagle id grass fireWebMar 29, 2024 · We conclude that the inhibition of protein import into mitochondria lacking the phosphate carrier/p32 is indirectly caused by a reduction of the mitochondrial membrane potential (Δγ), and we propose a model that the reduction of Δψ is due to the defective phosphate import, suggesting that phosphate transport is the primary function … eagle id gun shopWebThe mitochondrial phosphate carrier (PiC) is a mitochondrial solute carrier protein, which is encoded by SLC25A3 in humans. PiC delivers phosphate, a key substrate of oxidative … csi twenteWebThe SLC25A26 gene encodes a mitochondrial carrier that belongs to a family of transport proteins found mostly in the inner membranes of mitochondria. These proteins shuttle metabolites and cofactors through the mitochondrial membrane ( Agrimi et al., 2004 ). csi turn turn turn episodeWebThe sequences of the human and bovine genes for the phosphate carrier from the inner membranes of mitochondria have been determined. The genes have similar structures … csi turn turn turn cast