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Spi1 macrophage

WebWe demonstrate that HSF1 has a dual effect on SPI1/PU.1, a transcription factor essential for macrophage differentiation and whose deregulation can lead to the development of … Web4. apr 2024 · SPI1 mediates transcriptional activation of TPX2 and RNF2 to regulate the radiosensitivity of lung squamous cell carcinoma. Cytokine responses to LPS in …

Liver macrophages and inflammation in physiology and …

Web22. júl 2010 · Some findings suggest that high SPI1 expression may prevent macrophage migration [76]. Determination of the specific functions of SPI1 in the regulation of … WebDescription: Homo sapiens growth factor independent 1 transcriptional repressor (GFI1), transcript variant 2, mRNA. (from RefSeq NM_001127215) RefSeq Summary (NM_001127215): This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, … scrivener for genealogy research https://chriscrawfordrocks.com

Macrophage-specific gene functions in Spi1-directed innate …

Web20. dec 2024 · 例如，转录因子PU.1（也称为SPI1）在成纤维细胞极化和纤维生成中发挥主要作用。 PU.1既能使静止的成纤维细胞极化，又能使降解ECM的炎性成纤维细胞重新极化为产生ECM的纤维化表型。 此外，PU.1的失活使纤维化的成纤维细胞重新编程为静止的成纤维细胞，从而导致纤维化的消退。 在纤维化过程中，成肌纤维细胞与其他细胞类型之间也具 … Web30. jún 2024 · The functions and molecular mechanisms of SPI1-related protein (SPIB) were examined in cervical cancer (CC) cells. Methods: Cell proliferation, apoptosis, migration, … Web23. sep 2008 · A positive regulatory cascade mainly composed of HilD, HilA, and InvF, encoded in SPI-1, controls the expression of SPI-1 genes, whereas the two-component regulatory system SsrA/B, encoded in SPI-2, controls expression of SPI-2 genes. In this study, we report a previously undescribed transcriptional cross-talk between SPI-1 and … scrivener family tree

Anti-SPI1 antibody produced in rabbit Prestige Antibodies …

Category:SPI-1-encoded type III secretion system of Salmonella enterica is requir…

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Spi1 macrophage

WikiGenes - SPI1 - Spi-1 proto-oncogene

Web20. júl 2012 · The pro-inflammatory macrophages (also called M1 polarized or classically activated) comprise of inflammatory cells developed under stimulation by LPS and IFNγ. Such macrophages exhibit high phagocytic and antimicrobial activity and high expression of pro-inflammatory cytokines (e.g. TNFα, IL-8, IL-12, IL-23, IL-1) [ 4 ]. Web9. okt 2014 · AAP 4000000129 Jodi P19838 4790 NFKB1 protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 sickle-cell/Hb-C disease with crisis DOID:12910 lipopolysaccharide …

Spi1 macrophage

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Web23. jan 2024 · Macrophages (MΦ) are highly heterogenous and versatile innate immune cells involved in homeostatic and immune responses. Activated MΦ can exist in two extreme phenotypes: pro-inflammatory (M1) MΦ and anti-inflammatory (M2) MΦ. These phenotypes can be recapitulated in vitro by using ligands of toll-like receptors … WebThe macrophages in the liver activate and release both IL-1 and TNF-alpha. In turn, this activates leukocytes and sinusoidal endothelial cells to express ICAM-1. This results in tissue damage to the endothelium because of proteases, oxygen radicals, prostanoids and other substances from leukocytes.

WebSPI1 (OF, PU.1, SFPI1, SPI-1, SPI-A) protein expression summary. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell d evelopment. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in … WebImmunology Innate Immunity Macrophage / Inflamm. Share by email Anti-PU.1/Spi1 antibody [2G1] (ab88082) Datasheet; SDS; Submit ... Anti-PU.1/Spi1 antibody [2G1] (ab88082) at 5 µg/ml + tagged human recombinant protein fragment (the immunogen) at 0.2 µg Secondary

WebThe genes encoding for these three respective transcription factors have been mapped at 11p11.2 ( SPI1 ), 11q23.1 ( POU2AF1 ), and 19q13.2 ( POU2F2 ); these are chromosomes recurrently affected in HL [3]. Finally, PU.1 protein can inhibit both GATA-1 and GATA-2 transactivation function [12]. Addition of ETS1 and FLI1, two ETS family members ... Web22. júl 2024 · In the Spi1 over-expression dataset ( Spi1 pSIEW compared to pSIEW) 284 genes had an increased expression, 62 were down-regulated ( p < 0.05). In this …

WebIn PU.1 null mice, macrophages are totally absent and neutrophil development is severely impaired. Abnormalities are also detected in B cell compartment, which is blocked at a very early stage of maturation [ 34 ]. PU.1 has been shown to play a role also in early committing blood precursor stages.

Web25. jan 2024 · We identified the downregulated SPI1-TYROBP-FCER1G network in OS, which were significantly enriched in immune-related functions. We also defined a two-gene signature ( SPI1 / FCER1G) that can predict poorer OS overall survival and the attenuated immune infiltration when downregulated. pc bluetooth speaker choppyscrivener for the family historianWeb20. feb 2024 · Name: spi1-1cs Info: Enables spi1 with a single chip select (CS) line and associated spidev dev node. The gpio pin number for the CS line and spidev device node creation are configurable. N.B.: spi1 is only accessible on devices with a 40pin header, eg: A+, B+, Zero and PI2 B; as well as the Compute Module. pc bluetooth speakers battery life